Influenced by the Uruguayan artist Torres-García and the Argentinean Pettoruti, Polesello has taken the Constructivist tradition in Latin America, with its search for order through geometric abstraction, to a new level, defining geometry in human terms in his work that is both full of vitality and sensual interaction.

He has has numerous individual exhibitions in major galleries and museums in Latin America, Europe and the United States and his work is part of the permanent collections of the Museum of Modern Art in New York, the Solomon R. Guggenheim Museum in New York, and the Museum of Modern Art of Latin America in Washington D.C., among others.